S. Dawa

Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses

This study shows that inhibiting triglyceride synthesis in TB granulomas reduces bacterial load and inflammation by targeting DGAT1.

The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy

This study shows that sertraline enhances the effectiveness of TB antibiotics in macrophages and mice, suggesting it as a host-directed therapy to improve TB treatment.

Necrosis triggered by Mycobacterium tuberculosis alters macrophage triglyceride metabolism and inflammatory response in a DGAT1-dependent manner

This study shows that M. tuberculosis-induced necrosis promotes triglyceride storage in macrophages, which enhances inflammation, and that DGAT1 plays a key role in this process.