Author

D. Menon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

S. Dawa· 2 shared S. Gandotra· 2 shared A. Conway Morris· 1 shared A. J. Simpson· 1 shared A. J. Wood· 1 shared A. K. Bhaskar· 1 shared A. M. Vassallo· 1 shared A. Nandy· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

S. Dawa

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Author profile →

5 papers

Recent·Most cited

Regulation of membrane scission in yeast endocytosis

D. Menon, M. Kaksonen

This study investigates the role of Rvs BAR and SH3 domains in yeast endocytic scission, showing their importance in membrane invagination and vesicle formation.

bioRxiv · Aug 18, 2021Cell Biology

Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses

S. Dawa, D. Menon, P. Arumugam, A. K. Bhaskar, M. Mondal, V. K. Rao, S. Gandotra

This study shows that inhibiting triglyceride synthesis in TB granulomas reduces bacterial load and inflammation by targeting DGAT1.

bioRxiv · May 10, 2021Immunology

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

C. Dominguez Conde, T. Gomes, L. B. Jarvis, C. Xu, S. Howlett, D. Rainbow, O. Suchanek, H. King, L. Mamanova, K. Polanski, N. Huang, E. Fasouli, K. Mahbubani, M. Prete, E. Tuck, , S. A. Teichmann

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

bioRxiv · Apr 28, 2021Immunology

Complement C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling.

A. J. Wood, A. M. Vassallo, M.-H. Ruchard-Sparagano, J. Scott, C. Zinnato, C. Gonzalez-Tejedo, K. Kishore, C. D'Santos, A. J. Simpson, D. Menon, C. Summers, E. R. Chilvers, K. Okkenhaug, A. Conway Morris

This study identifies C5a-induced phosphoproteomic changes in human neutrophils that impair phagosomal maturation and acidification, leading to reduced killing of Staphylococcus aureus.

bioRxiv · Jan 17, 2020Immunology

Necrosis triggered by Mycobacterium tuberculosis alters macrophage triglyceride metabolism and inflammatory response in a DGAT1-dependent manner

N. Jaisinghani, S. Dawa, K. Singh, A. Nandy, D. Menon, P. Bhandari, G. Khare, A. Tyagi, S. Gandotra

This study shows that M. tuberculosis-induced necrosis promotes triglyceride storage in macrophages, which enhances inflammation, and that DGAT1 plays a key role in this process.

bioRxiv · Sep 11, 2017Immunology