A. Tyagi

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

Distinct mobility patterns of BRCA2 molecules at DNA damage sites

This study quantifies BRCA2 mobility patterns at DNA damage sites using advanced microscopy, revealing immobile and subdiffusive motions that may enhance repair efficiency.

Transcription Factor Gene Pea3 Regulates Erectile Function in Mice

This study shows that the Pea3 gene regulates erectile function in male mice, with Pea3 null males showing reduced erections and inability to deposit semen plugs during copulation.

Ovarian Tumor Mitochondria Exhibit Abnormal Phenotypes and Blunted Associations with Biobehavioral Factors

The paper examines mitochondrial content and function in ovarian tumors and their associations with biobehavioral factors, finding abnormal mitochondrial phenotypes and weaker biobehavioral correlations in tumors.

Gene loss during a transition to multicellularity

The paper examines gene loss in volvocine algae during multicellular evolution, finding that gene loss drives developmental complexity through novel protein interactions and network reconfiguration.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Targeted knockdown of ribulose-1, 5-bisphosphate carboxylase-oxygenase in rice mesophyll cells impact on photosynthesis and growth

This study knocks down Rubisco small subunit genes in rice mesophyll cells, reducing Rubisco protein content and CO2 assimilation, leading to decreased biomass and grain yield.

Human footprint differentially impacts genetic connectivity of four wide-ranging mammals in a fragmented landscape

The paper assesses how human activity affects genetic connectivity in four Indian mammals, finding species-specific impacts of landscape features on gene flow.

Necrosis triggered by Mycobacterium tuberculosis alters macrophage triglyceride metabolism and inflammatory response in a DGAT1-dependent manner

This study shows that M. tuberculosis-induced necrosis promotes triglyceride storage in macrophages, which enhances inflammation, and that DGAT1 plays a key role in this process.