Inhibition of mTORC1 signaling in aged rats counteracts the decline in muscle mass and reverses multiple parameters of muscle signaling associated with sarcopenia
G. A. Joseph, S. Wang, W. Zhou, G. Kimble, H. Tse, J. K. Eash, T. Shavlakadze, D. J. Glass
This study shows that inhibiting mTORC1 signaling in aged rats increases muscle mass and reverses sarcopenia-related gene expression changes.
bioRxiv · Mar 28, 2019Physiology