Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
M. S. Kaiser, G. Milan, S. Lin…·M. A. Ruegg
The paper reveals that mTORC1 promotes muscle atrophy by enhancing the ubiquitin-proteasome system through dual mechanisms, while also showing that proteome integrity depends on ubiquitination.