Cyclin A/cdk activity and FAM122A-dependent inhibition of PP2A-B55 are essential to trigger mitosis.
B. Lacroix, S. Vigneron, J. C. Labbé, L. Pintard, G. Labesse, A. Castro, T. Lorca
This study identifies FAM122A's role in inhibiting PP2A-B55 to initiate mitosis, showing its necessity in C. elegans and Xenopus systems.
bioRxiv · Jun 20, 2023 · PreprintCell Biology