Author

s. roche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Fourgous· 3 shared M. Pons· 2 shared P. P. Fort· 2 shared s. urbach· 2 shared V. Simon· 2 shared Y. Boublik· 2 shared A. Fernandez· 1 shared a. fournet· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

E. Fourgous

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lipid-mediated dimerization of membrane-anchored c-Src is driven by a cluster of lysine residues in the N-terminal SH4 domain.

I.-L. Mohammad, J. Carvajal, A. Fernandez, M. Taules, E. Fourgous, Y. Boublik, A.-L. Le Roux, S. Roche, M. Pons

This study identifies a cluster of lysine residues in the SH4 domain of c-Src that enhances lipid-mediated dimerization, increasing tyrosine phosphorylation in HEK293T cells.

bioRxiv · May 31, 2022 · PreprintBiophysics

SHED-dependent oncogenic signalling of the PEAK3 pseudo-kinase

y. OUNOUGHENE, E. fourgous, Y. Boublik, E. Saland, N. Guiraud, c. recher, s. urbach, P. P. Fort, J.-E. Sarry, d. fesquet, s. roche

This study identifies PEAK3 as an oncogenic pseudo-kinase that uses the SHED module to activate AKT signaling and promote cancer growth.

bioRxiv · Aug 30, 2021 · PreprintCancer Biology

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

E. APONTE, M. Lafitte, A. Sirvent, V. Simon, M. barbery, E. Fourgous, M. Maffei, F. Armand, R. Hamelin, J. Pannequin, P. P. Fort, M. Pons, s. roche

This study identifies the ULBR in Src as essential for its oncogenic activity by modulating membrane substrate phosphorylation.

bioRxiv · May 10, 2021Cancer Biology

A 3D human liver model of nonalcoholic steatohepatitis

M. Duriez, L. Hoet, A. Jacquet, S. Roche, M.-D. Bock, C. Rocher, G. Haussy, X. Vige, Z. Bocskei, T. Slavnic, V. Martin, J.-C. Guillemot, M. Didier, A. Kannt, C. Orsini, , A.-C. Le Fevre

The paper develops a 3D human liver model of nonalcoholic steatohepatitis that can be used for drug screening and disease study.

bioRxiv · Feb 7, 2020Cell Biology

Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.

M.-C. Gaillard, N. Broucqsault, J. Morere, C. Laberthonniere, C. Dion, C. Badja, S. Roche, K. Nguyen, F. Magdinier, J. Robin

This study examines the 3D chromatin organization of the 4q35 locus in FSHD patients, finding that D4Z4 contractions and SMCHD1 mutations alter spatial gene interactions and expression.

bioRxiv · Dec 7, 2018Cell Biology

Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation

c. lecointre, v. simon, c. kerneur, f. allemand, a. fournet, i. montarras, j.-l. pons, m. gelin, c. brignatz, s. urbach, g. labesse, s. roche

This study identifies a dimerization mechanism in the pseudo-kinase Pragmin that regulates protein tyrosine phosphorylation through interaction with CSK.

bioRxiv · Nov 27, 2017Biochemistry