Evolutionary BiologybioRxiv
Constrained mutational sampling of amino acids in HIV-1 protease evolution
J. I. Boucher, T. W. Whitfield, A. Dauphin…·D. N. A. Bolon
The paper investigates HIV-1 protease evolution by comparing experimental fitness landscapes with sequenced isolate data, showing mutational sampling influences multiple mutations.
DOI 10.1093/molbev/msz022