An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus
T. P. Sheahan, A. C. Sims, S. Zhou, C. Hill, S. R. Leist, A. Schaefer, M. Agostini, A. Pruijssers, A. J. Brown, G. Bluemling, M. Natchus, M. Saindane, A. Kolykhalov, G. Painter, R. Swanstrom, , R. S. Baric
This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.
bioRxiv · Mar 19, 2020 · PreprintMicrobiology