S. Zhou

A safe and effective method for thin cornea cross-linking

This paper introduces a new corneal cross-linking method using photo-initiators and visible blue light, which is safer and more effective for thin corneas than the standard riboflavin/UVA protocol.

Comparative analysis of culture- and ddPCR-based wastewater surveillance for carbapenem-resistant bacteria

This study compares culture-based and ddPCR methods for detecting carbapenem-resistant bacteria in wastewater, finding weak correlations between quantitative results due to method sensitivity and specificity differences.

A longitudinal atlas of post-viral lung regeneration reveals persistent injury-associated cell states

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection

The paper measures CSF proteins in HIV-1 infected and uninfected individuals, identifying patterns of protein changes associated with CNS injury and treatment effects.

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

Cryo-EM structures of human cone visual pigments

This study presents cryo-EM structures of human cone visual pigments in complex with G proteins, revealing their active state and mutations affecting spectral tuning.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.

The Arabidopsis PPR protein EMB1006 interacts with both EMB1270 and CFM2 to facilitate plastid clpP1 intron2 splicing

Long noncoding RNA Hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis

This study identifies Hottip as a regulator of skeletal homeostasis by suppressing the Ezh2/histone methylation axis, affecting osteoblast and osteoclast differentiation.

The roles of DDR2 and substrate stiffness on cancer cell transcriptome and proliferation

This study investigates how DDR2 and substrate stiffness affect cancer cell proliferation and transcriptome, revealing distinct regulatory mechanisms.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

Integrative analysis of the methylome and transcriptome of tomato fruit (Solanum lycopersicum L.) induced by postharvest handling

This study examines how postharvest handling affects the methylome and transcriptome of tomato fruit, revealing epigenetic and gene expression changes linked to ripening speed and quality.

HybriSeq: Probe-based Device-free Single-cell RNA Profiling

HybriSeq enables sensitive single-cell RNA profiling by combining in situ hybridization, split-pool barcoding, and sequencing to detect transcripts without end bias.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

N4-Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness

This study shows that N4-hydroxycytidine and its prodrug molnupiravir reduce RNA-virus-induced encephalitis by producing less fit viruses with G-to-A and C-to-U mutations.

ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

ME3BP-7 is a novel 3BP formulation that resists serum degradation and kills MCT1-high pancreatic cancer cells with low toxicity in mice.

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

This study shows TGFβ signaling is essential for maintaining alveolar type 1 cell fate and regulates the alveolar matrisome through integrin transcription and mechanotransduction.

S2' cleavage site plays a decisive role in expansion of Vero cell tropism by infectious bronchitis virus HV80, with Q855H promoting cell-to-cell fusion

This study identifies the S2' cleavage site and Q855H mutation as critical for HV80's Vero cell tropism and cell-to-cell fusion.

Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

Scoring thermal limits in small insects using open-source, computer assisted motion detection.

This paper introduces an open-source tool for automated scoring of thermal tolerance in insects using motion detection, showing it accurately measures thermal limits and increases throughput.

Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti CD16 antibody revealed superior antitumor effects toward myeloid leukemia

This study develops bifunctional CAR-NK cells targeting CD33 with anti-CD16 antibody secretion, showing improved antitumor effects against AML in vitro and in vivo.

Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration

This study identifies Atf3 as critical for pulmonary endothelial regeneration after influenza infection, showing its role in endothelial proliferation, angiogenesis, and preventing alveolar damage.

Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

This study shows that mesenchymal stem cells (MSCs) reduce CAR-T cell effectiveness against lymphoma by altering the microenvironment via stanniocalcin-1.