Author

A. Kolykhalov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

M. G. Natchus· 4 shared C. M. Lieber· 3 shared G. R. Painter· 3 shared R. Cox· 3 shared R. K. Plemper· 3 shared Z. M. Sticher· 3 shared A. L. Greninger· 2 shared H.-J. Kang· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

M. G. Natchus

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

R. K. Plemper, R. Cox, J. D. Wolf, N. A. P. Lieberman, C. M. Lieber, H.-J. Kang, Z. M. Sticher, J.-J. Yoon, M. K. Andrews, M. Govindarajan, R. E. Krueger, E. B. Sobolik, M. G. Natchus, A. Gewirtz, R. deSwart, , A. L. Greninger

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

bioRxiv · Sep 1, 2023Microbiology

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

R. Cox, C. M. Lieber, J. D. Wolf, A. Karimi, N. A. P. Lieberman, Z. M. Sticher, P. Roychoudhury, M. K. Andrews, R. E. Krueger, M. G. Natchus, G. R. Painter, A. Kolykhalov, A. L. Greninger, R. K. Plemper

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

bioRxiv · Nov 20, 2022 · PreprintMicrobiology

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection

G. R. Bluemling, S. Mao, M. G. Natchus, W. Painter, S. Mulangu, M. Lockwood, A. D. L. R. De La Rosa, T. Brasel, J. E. Comer, A. N. Freiberg, A. Kolykhalov, G. R. Painter

This study evaluates the efficacy of EIDD-1931, a ribonucleoside analog, in preventing and treating lethal Ebola virus infection in mice.

bioRxiv · Oct 18, 2022 · PreprintMicrobiology

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

T. P. Sheahan, A. C. Sims, S. Zhou, C. Hill, S. R. Leist, A. Schaefer, M. Agostini, A. Pruijssers, A. J. Brown, G. Bluemling, M. Natchus, M. Saindane, A. Kolykhalov, G. Painter, R. Swanstrom, , R. S. Baric

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

bioRxiv · Mar 19, 2020 · PreprintMicrobiology