Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function
S. Verma, D. Crawford, A. Khateb, Y. Feng, E. Sergienko, G. Pathria, C.-T. Ma, S. H. Olson, D. A. Scott, R. Murad, E. Ruppin, M. Jackson, Z. A. Ronai
This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.
bioRxiv · Oct 22, 2021Cancer Biology