Author

R. Murad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:bulk RNA-seq· 6 Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:genetic perturbation / CRISPR· 3 Organism:mouse· 3

Frequent Co-Authors

Z. A. Ronai· 4 shared E. Ruppin· 3 shared B. A. Grimmig· 2 shared E. Y. Snyder· 2 shared R. N. McVicar· 2 shared S. L. Leibel· 2 shared Y. Feng· 2 shared A. Alvarado· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCancer Biology

Z. A. Ronai

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The effects of cell-cell orientation in modeling the hallmarks of lung cancer in vitro

A. S. Espinoza, R. N. McVicar, D. Finlay, R. Murad, K. Vuori, B. A. Grimmig, A. Bush, E. Smith, T. Mandel-Clausen, H. M. McGee, E. Y. Snyder, S. L. Leibel

This study compares 3D tumoroid and 2D cultures of lung cancer cells to assess how cell-cell orientation affects cancer-related features and finds that 3D cultures better mimic primary human lung cancer.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Bone Morphogenetic Protein (BMP) signaling upregulates expression of ID1 and ID3 in pancreatitis and pancreatic ductal adenocarcinoma

M. K. Raghunathan, K. M. Scully, A. Wehrmaker, R. Murad, A. M. Lowy, H. C. Maurer, K. E. DelGiorno, P. Itkin-Ansari

This study identifies BMP signaling as a driver of ID1 and ID3 upregulation in pancreatitis and PDAC, linking it to poor patient survival and disease progression.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential.

B. Van Espen, H. Z. Oo, C. Collins, L. Fazil, A. Molinolo, R. Murad, M. Gleave, Z. A. Ronai

This study shows RNF185 limits prostate cancer migration and metastasis by controlling COL3A1 expression.

bioRxiv · Jun 29, 2023Cancer Biology

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

S. L. Leibel, R. N. McVicar, R. Murad, E. M. Kwong, A. E. Clark, A. Alvarado, B. A. Grimmig, R. Nuryyev, R. E. Young, J. C. Lee, W. Peng, Y. P. Zhu, E. Griffis, C. J. Nowell, B. James, , E. Y. Snyder

This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.

bioRxiv · Jan 26, 2023 · PreprintImmunology

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

K. Barbosa, A. Deshpande, M. E. Perales, P. Xiang, R. Murad, A. Minkina, N. A. Robertson, F. Schischlik, X. Lei, Y. Sun, A. Brown, D. Amend, I. Jeremias, J. G. Doench, K. Humphries, , A. J. Deshpande

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

bioRxiv · Dec 12, 2022 · PreprintCancer Biology

Melanoma-intrinsic NR2F6 activity regulates anti-tumor immunity

H. Kim, Y. Feng, R. Murad, V. Klepsch, G. Baier, Z. A. Ronai

This study identifies NR2F6 as a melanoma-intrinsic regulator of anti-tumor immunity, showing that its inhibition enhances immunotherapy response and tumor suppression.

bioRxiv · Sep 14, 2022 · PreprintCancer Biology

Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma

M. Scortegagna, Y. Du, L. M. Bradley, K. Wang, E. Ruppin, R. Murad, Z. A. Ronai

This study shows that Siah1a/2 ubiquitin ligases regulate alveolar macrophage differentiation, and their loss promotes lung adenocarcinoma by increasing immature macrophages and pro-tumorigenic inflammation.

bioRxiv · Sep 14, 2022Cancer Biology

Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

S. Verma, D. Crawford, A. Khateb, Y. Feng, E. Sergienko, G. Pathria, C.-T. Ma, S. H. Olson, D. A. Scott, R. Murad, E. Ruppin, M. Jackson, Z. A. Ronai

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

bioRxiv · Oct 22, 2021Cancer Biology

Disrupting β-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression

G. T. Chen, D. F. Tifrea, R. Murad, Y. Lyou, A. Mortazavi, R. A. Edwards, M. L. Waterman

This study shows that reducing Wnt signaling in colon cancer cells increases their invasiveness and identifies gene markers predictive of poor patient outcomes.

bioRxiv · Jul 16, 2019Cancer Biology