Cancer BiologybioRxiv
Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
G. Rodriguez-Berriguete, M. Ranzani, R. Prevo…·G. S. Higgins
This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.
DOI 10.1158/1078-0432.ccr-22-2977