PhysiologyJournal of the American Heart AssociationPeer-reviewed
MK2-deficient mice are bradycardic and display delayed hypertrophic remodelling in response to a chronic increase in afterload
M. Ruiz, M. Khairallah, D. Dingar…·B. G. Allen
This study examines the cardiac phenotype of MK2-deficient mice, finding altered autonomic regulation, increased metabolic gene expression, reduced mitochondrial Ca2+-sensitivity, and delayed hypertrophic remodeling in response to pressure overload.
DOI 10.1161/jaha.120.017791