Cell BiologybioRxiv
Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms
A. M. Cardozo Gizzi, D. I. Cattoni, J.-B. Fiche…·M. Nollmann
The paper introduces Hi-M, a microscopy-based method to simultaneously visualize genome organization and transcription in single nuclei of Drosophila embryos, revealing changes in 3D chromatin structure during transcriptional activation.
DOI 10.1016/j.molcel.2019.01.011