BiochemistrybioRxivPreprint
A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs
Seher Alam, Maria Joao Almeida A Silva Pires, Gabriel Tidestav…·Mikael Altun
This paper introduces a cell-based platform to assess PROTACs targeting NUDT5, identifying a VHL-dependent degrader despite poor in vitro binding and showing CRBN-dependent degraders are ineffective.
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