Author

George E. Tsourdinis

Endeavor Health

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Neuroscience· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

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Charlotte Holas· 1 shared Junling YangiD· 1 shared Ken-ichiro FukuchiiD· 1 shared Mark Maienschein‐ClineiD· 1 shared Robert LalondeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperNeuroscience

Charlotte Holas

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1 paper

Recent·Most cited

NeuroscienceFrontiers in ImmunologyPeer-reviewedFeb 24, 2026

MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer's disease

Junling Yang, George E. Tsourdinis, Charlotte Holas…·Ken-ichiro Fukuchi

This study shows that miR-34a deficiency in Alzheimer's disease mice increases type I IFN signaling and microglial activation, linked to improved memory and altered amyloid-beta ratios.

4 citationstop 1%

mousebulk RNA-seq

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