Gilles P. van Wezel

This study shows that Streptomyces sp. ATMOS43 detoxifies fusaric acid through amino acid conjugation, protecting plants from Fusarium pathogens.

This paper designs a synthetic microbial community for lignin degradation by integrating ecological and trait-based selection, showing enhanced lignin conversion through functional partitioning.

The paper identifies a family of over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage function, demonstrating their conservation and novel compound production.

The paper constructs a regulatory atlas of Streptomyces and related actinomycetes using DAP-seq and ChIP-seq, revealing conserved and divergent transcriptional networks.

This study shows Chitinophaga pinensis can switch between filamentous and spherical morphologies with distinct transcriptional profiles, impacting its behavior and interactions in the plant microbiome.

This study reconstructs microbial consortia responsible for disease suppression in plants by combining dilution-to-extinction experiments with genome-resolved synthetic ecology.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

This study identifies a novel family of bacitracin-type antibiotics, paenitracins, produced by Paenibacillus species using a metabolomics-genomics workflow.

This study shows that serotonin is metabolized by Pseudomonas fluorescens into 5-HIAA and other products, enhancing its resistance to oxidative stress in serotonin-rich environments.

This paper identifies essential structural domains of DivIVA in Actinomycetota by analyzing truncated variants and chimeric proteins, showing that polar growth depends on Actinomycetota-specific amino acid motifs.

This study shows that plant colonization induces antifungal compound production in root-associated microbes, enhancing plant resistance to fungal pathogens.

This paper identifies a novel aminosugar metabolic pathway in Streptomyces that regulates development and antibiotic production through GlcNAc sensing.

The paper identifies and analyzes three variants of lipase A from Streptomyces that show PET-degrading activity, with S2LipA demonstrating efficient degradation of BHET and PET films.

LogoMotif provides a database of transcription factor binding sites in Actinobacteria, including position weight matrices and predicted interactions, to aid in gene regulation and compound discovery.

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

The paper identifies RokL6 as a regulator that controls the expression of the MFS transporter SCO1448, which protects Streptomyces coelicolor from glucosamine toxicity by exporting toxic metabolites.

FERMO is a dashboard that automates the prioritization of molecular features from mass spectral data to link molecules to phenotypes.

This paper identifies Gbn, a novel GATC-binding NAP in Streptomyces, showing its impact on development and gene expression through chromatin binding and transcriptomic analysis.

The paper compares metabolic differences between Streptomyces coelicolor strains M1152 and M145 using omics data and a genome-scale model to identify metabolic changes affecting heterologous compound production.

RRE-Finder identifies RRE domains across RiPP biosynthetic gene clusters, discovering novel classes and providing a dataset for further biochemical study.

The paper shows that mutations in SsgB, a protein that recruits FtsZ, cause longitudinal cell division in Streptomyces by altering septum placement.

The paper shows that ferroverdins and bagremycins, two metabolites with different bioactivities, are produced from the same BGC, with their formation depending on iron availability.

The paper identifies and characterizes novel catecholate-hydroxamate siderophores, qinichelins, from Streptomyces sp. MBT76, revealing their biosynthesis involves multiple gene clusters.

The paper characterizes the alanine racemase from Streptomyces coelicolor, showing its essential role in D-Ala production and sensitivity to D-cycloserine.

PREDetector 2.0 improves gene regulatory network prediction by offering interactive parameter tuning, enhanced visualization, and expanded database access for bacterial genomes.