MicrobiologybioRxivPreprint
Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases
Nick Lee, Manmeet Bhalla, Joana M. Pereira…·Elsa N. Bou Ghanem
This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.