Elsa N. Bou Ghanem

This study identifies CD73 as a regulator of neutrophil responsiveness to type I interferon, which impairs antibacterial responses during secondary pneumococcal pneumonia following influenza A virus infection.

This study shows that neutrophils suppress regulatory T cells to enhance antibody responses to the pneumococcal conjugate vaccine in mice and humans.

This study shows that aging leads to senescent-like neutrophils in mice, which have reduced antimicrobial function and altered transcriptional responses to Streptococcus pneumoniae.

This study shows that aged neutrophils have impaired antimicrobial activity against antibody-opsonized pneumococci due to imbalanced ERK1/2 activation, which can be improved by ERK1/2 inhibition.

This study shows that adenosine 2B receptor signaling impairs neutrophil killing of antibody-opsonized pneumococci in young vaccinated mice, reducing vaccine efficacy, but not in aged mice.

This study examines sex-based differences in immune responses to the pneumococcal conjugate vaccine in mice, finding males have reduced antibody production and vaccine efficacy compared to females.

This study shows that activating A1 adenosine receptors in aged mice enhances early neutrophil recruitment to the lungs during Streptococcus pneumoniae infection, improving bacterial control.

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.