Author

O. Khalimonchuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. R. Reddi· 3 shared I. Bohovych· 3 shared J. V. Dietz· 3 shared A. E. Medlock· 2 shared M. M. Willoughby· 2 shared O. Martinez-Guzman· 2 shared A. Barrientos· 1 shared A. Janer· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

A. R. Reddi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome

H. Zhong, A. Janer, O. Khalimonchuk, H. Antonicka, E. Shoubridge, A. Barrientos

This study identifies BOLA3 and NFU1 as critical for mitoribosome iron-sulfur cluster assembly, linking their dysfunction to mitochondrial and metabolic disorders.

bioRxiv · May 27, 2023Biochemistry

Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase

J. V. Dietz, M. M. Willoughby, R. B. Piel, T. A. Ross, I. Bohovych, H. G. Addis, J. L. Fox, W. N. Lanzilotta, H. A. Dailey, J. A. Wohlschlegel, A. R. Reddi, A. E. Medlock, O. Khalimonchuk

The paper investigates the role of MICOS in regulating ferrochelatase activity and heme biosynthesis in yeast, showing that MICOS disruption leads to toxic tetrapyrrole accumulation.

bioRxiv · Jun 1, 2021Biochemistry

Protease OMA1 Modulates Mitochondrial Bioenergetics and Ultrastructure through Dynamic Association with MICOS Complex

M. Ponte Viana, R. M. Levytskyy, R. Anand, A. S. Reichert, O. Khalimonchuk

This study identifies OMA1's role in maintaining mitochondrial ultrastructure and bioenergetics through its interaction with the MICOS complex, showing its importance in cellular stress responses and apoptosis.

bioRxiv · Nov 24, 2020Biochemistry

The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus.

O. Martinez-Guzman, M. M. Willoughby, A. Saini, J. V. Dietz, I. Bohovych, A. E. Medlock, O. Khalimonchuk, A. R. Reddi

The paper develops a live-cell assay to study heme trafficking and identifies ALAS and GTPases as regulators of heme mobilization from mitochondria to the nucleus.

bioRxiv · Aug 13, 2019 · PreprintCell Biology

Mitochondrial-nuclear heme trafficking is regulated by GTPases that control mitochondrial dynamics.

O. Martinez-Guzman, J. V. Dietz, I. Bohovych, A. W. Medlock, O. Khalimonchuk, A. R. Reddi

The paper investigates mitochondrial-nuclear heme trafficking and identifies GTPases regulating this process, showing heme moves faster to the nucleus than to the matrix or cytosol.

bioRxiv · Feb 4, 2019 · PreprintCell Biology