Cancer BiologybioRxiv
Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53
H. A. Segeren, E. A. van Liere, F. M. Riemers…·B. Westendorp
This study shows that oncogenic RAS increases sensitivity to ATR/CHK1 inhibitors by suppressing P53 transcriptional responses to replication stress.
DOI 10.1038/s41388-022-02291-0