Author

B. Westendorp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

A. de Bruin· 3 shared F. M. Riemers· 3 shared E. A. van Liere· 2 shared H. A. Segeren· 2 shared K. Strijbis· 2 shared A. Villunger· 1 shared A. Z. Mykytyn· 1 shared B. Haagmans· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. de Bruin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance.

H. A. Segeren, K. Wierenga, F. M. Riemers, E. A. van Liere, B. Westendorp

The paper identifies FOXM1 expression levels as a factor in replication stress tolerance in oncogenic RAS-expressing cells using single-cell RNA sequencing and drug combination experiments.

bioRxiv · Mar 26, 2024Cancer Biology

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C

C. Segui-Perez, D. Stapels, Z. Ma, J. Su, E. Passchier, B. Westendorp, W. Wu, J. P. van Putten, K. Strijbis

This study shows MUC13 regulates tight junction proteins and intestinal barrier integrity through Protein Kinase C, with deletion of MUC13 increasing TJ protein levels and altering barrier function.

bioRxiv · Oct 27, 2022Cell Biology

Glycosylated extracellular mucin domains protect against SARS CoV-2 infection at the respiratory surface

M. Chatterjee, L. Z. X. Huang, A. Z. Mykytyn, C. Wang, M. M. Lamers, B. Westendorp, R. W. Wubbolts, J. P. M. v. Putten, B. J. Bosch, B. Haagmans, K. Strijbis

This study shows that glycosylated mucin domains on respiratory epithelial cells restrict SARS-CoV-2 infection by reducing viral entry.

bioRxiv · Oct 29, 2021Microbiology

Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53

H. A. Segeren, E. A. van Liere, F. M. Riemers, A. de Bruin, B. Westendorp

This study shows that oncogenic RAS increases sensitivity to ATR/CHK1 inhibitors by suppressing P53 transcriptional responses to replication stress.

bioRxiv · Jun 14, 2021Cancer Biology

PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis

V. C. Sladky, K. Knapp, T. G. Szabo, L. Bongiovanni, H. van den Bos, D. C. J. Spierings, B. Westendorp, T. Stojakovic, H. Scharnagl, G. Timelthaler, K. Tsuchia, M. Pinter, F. Foijer, A. de Bruin, T. Reiberger, , A. Villunger

This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.

bioRxiv · May 13, 2020 · PreprintCancer Biology

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage.

H. S. Segeren, L. M. van Rijnberk, E. Moreno, F. M. Riemers, R. Yuan, R. Wubbolts, A. de Bruin, B. Westendorp

The paper shows that high E2F transcription in cancer cells prevents cell cycle exit after DNA damage, leading to genomic instability and reduced drug sensitivity.

bioRxiv · Mar 19, 2020Cancer Biology