Evolutionary BiologybioRxiv
A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species-specificity
J. S. Takeuchi, K. Fukano, M. Iwamoto…·K. Watashi
The paper shows a single mutation in the NTCP receptor determines HBV infection specificity by showing how virus-induced positive selection at aa 158 alters host susceptibility.