M. Iwamoto

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR

The paper characterizes genome-encoded ABCF proteins in Gram-positive bacteria, showing their roles in intrinsic antibiotic resistance and revealing structural and regulatory mechanisms.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

Binding of cardiolipin to the KcsA channel at the membrane outer leaflet allosterically opens the inner gate

The paper shows cardiolipin binding to KcsA's outer leaflet triggers an allosteric opening of the inner gate via interactions with Arg64 and Arg89.

Mechanosensory trichome cells evoke a mechanical stimuli-induced immune response in plants

The paper shows that trichome cells in Arabidopsis detect mechanical stimuli from raindrops, triggering calcium waves that activate immune responses against pathogens.

Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β

This study identifies bisphenol A derivatives as novel coactivator binding inhibitors for estrogen receptor β, showing dual agonist/antagonist activities and a new ligand interaction site.

Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution

This study identifies novel deltaviruses in birds and mammals, revealing evolutionary relationships and transmission dynamics of deltaviruses.

Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast

This study reveals asymmetrical localization of the Nup107-160 subcomplex in fission yeast, contrasting with symmetrical localization in other organisms, and shows its necessity for cell cycle progression.

A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species-specificity

The paper shows a single mutation in the NTCP receptor determines HBV infection specificity by showing how virus-induced positive selection at aa 158 alters host susceptibility.

An evolutionary switch in the specificity of an endosomal CORVET tether underlies formation of regulated secretory vesicles in the ciliate Tetrahymena thermophila

The paper identifies an evolutionary switch in the specificity of a CORVET tether in Tetrahymena thermophila that enables the formation of regulated secretory vesicles called mucocysts.

Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena

The paper identifies compositionally distinct nuclear pore complexes in the macronucleus and micronucleus of Tetrahymena, highlighting functional specialization through unique nucleoporin localization.