Time-resolved cryo-EM of G protein activation by a GPCR
M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis
This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.
bioRxiv · Mar 20, 2023Pharmacology & Toxicology