Pharmacology & ToxicologybioRxiv
Time-resolved cryo-EM of G protein activation by a GPCR
M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi…·G. Skiniotis
This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.
DOI 10.1038/s41586-024-07153-1