Author

D. Hilger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. K. Kobilka· 6 shared G. Skiniotis· 2 shared J. M. Mathiesen· 2 shared K. Krishna Kumar· 2 shared P. W. Hildebrand· 2 shared A. B. Seven· 1 shared A. Beck-Sickinger· 1 shared A. C. Kruse· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersBiochemistry

B. K. Kobilka

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Time-resolved cryo-EM of G protein activation by a GPCR

M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

bioRxiv · Mar 20, 2023Pharmacology & Toxicology

Negative allosteric modulation of the glucagon receptor by RAMP2

K. Krishna Kumar, E. O'Brien, C. Habrian, N. R. Latorraca, H. Wang, I. Tuneew, E. Montabana, S. Marqusee, D. Hilger, E. Y. Isacoff, J. M. Mathiesen, B. K. Kobilka

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry

Uncovering patterns of atomic interactions in static and dynamic structures of proteins

A. J. Venkatakrishnan, R. Fonseca, A. K. Ma, S. A. Hollingsworth, A. Chemparathy, D. Hilger, A. J. Kooistra, R. Ahmari, M. M. Babu, B. K. Kobilka, R. Dror

The paper develops tools for analyzing interatomic interactions in protein structures and simulations, creating a web resource to identify functional interaction patterns in GPCRs, G proteins, kinases, and muscarinic receptors.

bioRxiv · Nov 13, 2019 · PreprintBiophysics

Structural insights into ligand efficacy and activation of the glucagon receptor

D. Hilger, K. Krishna Kumar, H. Hu, M. F. Pedersen, L. Giehm, J. M. Mathiesen, G. Skiniotis, B. K. Kobilka

The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.

bioRxiv · Jun 5, 2019 · PreprintBiophysics

Local membrane charge regulates β2 adrenergic receptor coupling to Gi

M. J. Strohman, S. Maeda, D. Hilger, M. Masureel, Y. Du, B. K. Kobilka

This study shows that local membrane charge affects β2AR coupling to Gi and Gs proteins, with negative charges inhibiting Gi coupling and promoting Gs coupling.

bioRxiv · Aug 25, 2018Biochemistry

Platform for rapid nanobody discovery in vitro

C. McMahon, A. S. Baier, S. Zheng, R. Pascolutti, J. X. Ong, S. C. Erlandson, D. Hilger, A. M. Ring, A. Manglik, A. C. Kruse

This paper presents an in vitro platform for rapid nanobody discovery using yeast surface display, demonstrating its application to various antigens including lipid flippase and G protein-coupled receptors.

bioRxiv · Jun 16, 2017Biochemistry