Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial Keratitis
D. S. J. Ting, E. T. L. Goh, V. Mayandi, J. Busoy, T. Aung, M. Periayah, M. Nubile, L. Mastropasqua, D. Said, H. Htoon, A. Veluchamy, R. Beuerman, R. Lakshminarayanan, I. Mohammed, H. Dua
This paper develops a hybrid antimicrobial peptide (CaD23) from human-derived host defense peptides, showing high efficacy against Gram-positive bacteria and reduced antimicrobial resistance compared to amikacin.
bioRxiv · Apr 22, 2021Microbiology