J. Moore

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Beta3 accelerates microtubule plus end maturation through a divergent lateral interface

This study identifies how TUBB3/{beta}3 accelerates microtubule plus end maturation through specific lateral interface residues, affecting drug resistance and dynamics.

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

Broad-Spectrum Coronavirus Inhibitors Discovered by Modeling Viral Fusion Dynamics

The paper identifies broad-spectrum coronavirus inhibitors using molecular dynamics and AI docking, showing efficacy against SARS-CoV-2 and related viruses in cell and mouse models.

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade

This study identifies a biomarker, {beta}Alt, that predicts immune checkpoint blockade response in cold tumors by integrating TGF{beta} signaling, DNA repair, and immune context signatures.

Indirect effects of habitat amount mediated by habitat configuration determine bat diversity at the landscape-scale in Peninsular Malaysia

This study shows that habitat amount and configuration interact to influence bat diversity in Peninsular Malaysia, with indirect effects of habitat loss through configuration often outweighing direct effects.

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

This study investigates how glycan heterogeneity on HIV-1 Env contributes to persistent infectivity despite neutralizing antibody (NAb) treatment, showing that glycan variants affect antibody binding and neutralization efficacy.

TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells

This study identifies TTLL12 as a novel microtubule regulator required for primary ciliary axoneme formation in polarized epithelial cells.

Foraging guild modulates insectivorous bat responses to habitat loss and insular fragmentation in peninsular Malaysia

This study examines how habitat loss and fragmentation affect insectivorous bat diversity and activity in Malaysian islands, finding that forest foragers decline with isolation while edge foragers increase in smaller islands.

Change in functional trait diversity mediates the effects of nutrient addition on grassland stability

This study examines how nutrient addition affects grassland stability through changes in functional trait diversity and finds that these effects are generally weak compared to direct impacts.

Testing the ion-current model for flagellar length sensing and IFT regulation

This study tests the ion-current model for flagellar length sensing by measuring Ca2+ levels and IFT injection in Chlamydomonas, finding no support for the model's predictions.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

Prospective Motion Correction and Automatic Segmentation of Penetrating Arteries in Phase Contrast MRI at 7 T

This paper develops a prospective motion correction method for 7 T phase contrast MRI of penetrating arteries and evaluates its effectiveness using CNN-based segmentation.

Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis

This study examines the microbiota of adults with cystic fibrosis (CF) and finds low diversity and instability in sinus microbial communities, linked to inflammation and worse sinus disease.

Novel murine models of post-implantation and midgestional malaria-induced preterm birth

This study introduces three novel murine models of malaria-induced preterm birth at different gestational stages and identifies distinct transcriptomic and parasitemia patterns associated with each model.

Starvation induces shrinkage of the bacterial cytoplasm

This study shows that starvation causes E. coli to shrink its inner membrane and cytoplasm, driven by water loss, and that the Tol-Pal system is essential for recovery.

Evolution and adaptation of Pseudomonas aeruginosa in the paranasal sinuses of people with cystic fibrosis

This study identifies three evolutionary genetic routes of Pseudomonas aeruginosa adaptation in the sinuses of people with cystic fibrosis, suggesting sinuses may be an early site of pathoadaptation before lung infections.

A three-dimensional Air-Liquid Interface Culture Model for the Study of Epstein-Barr virus Infection in the Nasopharynx

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure

This study infects nonhuman primates with SARS-CoV-2 via airborne exposure and compares disease progression across species.

Elevated soluble Galectin-3 as a marker of chemotherapy efficacy in Breast cancer patients: a prospective study

This study shows that elevated soluble Galectin-3 in plasma or stromal tissue after chemotherapy correlates with better prognosis and longer disease-free survival in breast cancer patients.

Tubulin recycling limits cold tolerance

This study investigates how temperature affects microtubule dynamics in budding yeast, finding that tubulin recycling limits cold tolerance and that disrupting this process can improve cold resistance.

SUCCESSFUL DEMONSTRATION OF ASSISTED GENE FLOW IN THE THREATENED CORAL ACROPORA PALMATA ACROSS GENETICALLY-ISOLATED CARIBBEAN POPULATIONS USING CRYOPRESERVED SPERM

This study demonstrates that cryopreserved coral sperm can enable successful assisted gene flow between genetically-isolated Caribbean populations of Acropora palmata, producing viable larvae and showing reproductive compatibility across populations.

Geometry alone influences stem cell differentiation in a precision 3D printed stem cell niche

The paper shows that precise 3D printed geometric structures influence stem cell differentiation without exogenous signaling molecules.

A unified model for microtubule rescue

The paper tests two models for microtubule rescue using simulations and experiments, supporting a lattice-driven model with embedded rescue sites influenced by divalent cations.

A Fixed Moderate-dose Combination of Tiletamine+Zolazepam Outperforms Midazolam in Induction of Short-term Immobilization of Ball Pythons (Python regius)

This study compares the effectiveness of tiletamine+zolazepam and midazolam in anesthetizing ball pythons, finding that the combination provides more reliable immobilization.

The structured demography of open populations in fluctuating environments

The paper introduces stochastic models for population dynamics in fluctuating environments and derives analytic methods to understand their long-term behavior.

Restoration of Eastern oyster populations with positive density dependence

The paper models positive density dependence in Eastern oyster populations to determine effective restoration strategies through stock and habitat enhancement.