Author

R. Lakshminarayanan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. S. Verma· 2 shared D. S. J. Ting· 2 shared E. T. L. Goh· 2 shared I. Mohammed· 2 shared L. Mastropasqua· 2 shared M. Nubile· 2 shared A. Veluchamy· 1 shared A.-T. Phan· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

C. S. Verma

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Author profile →

3 papers

Recent·Most cited

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

C. Jelinska, S. Kannan, F. R. Winnerdy, Y. Frosi, S. R. Ramlan, R. Lakshminarayanan, C. J. Brown, A.-T. Phan, D. Rhodes, C. S. Verma

The paper designs and tests stapled peptides that inhibit DAXX, a protein involved in cancer, showing they enter cells and disrupt its interactions with other proteins.

bioRxiv · Sep 25, 2022Biochemistry

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights from Experimental and Molecular Dynamics Simulations Studies

D. S. J. Ting, J. Li, C. S. Verma, E. T. L. Goh, M. Nubile, L. Mastropasqua, D. G. Said, R. W. Beuerman, R. Lakshminarayanan, I. Mohammed, H. S. Dua

This study evaluates the synergistic interaction of CaD23 with antibiotics and identifies its membrane-permeabilizing mechanism through experimental and molecular dynamics simulations.

bioRxiv · Jun 26, 2021Microbiology

Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial Keratitis

D. S. J. Ting, E. T. L. Goh, V. Mayandi, J. Busoy, T. Aung, M. Periayah, M. Nubile, L. Mastropasqua, D. Said, H. Htoon, A. Veluchamy, R. Beuerman, R. Lakshminarayanan, I. Mohammed, H. Dua

This paper develops a hybrid antimicrobial peptide (CaD23) from human-derived host defense peptides, showing high efficacy against Gram-positive bacteria and reduced antimicrobial resistance compared to amikacin.

bioRxiv · Apr 22, 2021Microbiology