Cancer BiologybioRxiv
Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error
N. Umbreit, C.-Z. Zhang, L. D. Lynch…·D. Pellman
This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.
DOI 10.1126/science.aba0712