An Igh novel enhancer modulates antigen receptor diversity by determining locus conformation
K. H. Bhat, S. Priyadarshi, S. L. Naiyer, X. Qu, H. Faroque, E. Kleiman, J. Xu, X. Lei, J. F. Cantillo, R. Wuerffel, N. Baumgarth, J. Liang, A. L. Kenter, A. Feeney
The paper identifies a novel enhancer, NE1, that modulates Igh locus conformation and influences V(D)J recombination by altering chromatin structure and VH gene usage.
bioRxiv · May 23, 2022 · PreprintImmunology