H. Gowher

RyR2/IRBIT regulates insulin gene transcription, insulin content, and secretion in the insulinoma cell line INS-1

Deletion of RyR2 or IRBIT in INS-1 cells reduces insulin content and secretion, with RyR2 also decreasing IRBIT levels and affecting DNA methylation and proteome regulation.

The Acute Myeloid Leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme

The paper shows that the DNMT3A Arg882His variant in AML acquires DNMT3B-like substrate preference, potentially contributing to its oncogenic effect.