BiochemistrybioRxiv
The Acute Myeloid Leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
A. B. Norvil, L. AlAbdi, B. Liu…·H. Gowher
The paper shows that the DNMT3A Arg882His variant in AML acquires DNMT3B-like substrate preference, potentially contributing to its oncogenic effect.
DOI 10.1093/nar/gkaa139