Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures
S. Yoon, E. U. Anaya, J. Sachithanandham…·A. Pekosz
This study shows A-lineage SARS-CoV-2 variants evolved mutations similar to B-lineage VOCs, improving replication in human nasal cells and showing temperature-dependent growth advantages.