C. B. Brooke

Stratification of viral shedding patterns in saliva of COVID-19 patients

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome

The paper identifies cryptic proteins from deletion-containing viral genomes that inhibit influenza virus replication and expand its proteome.

Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection

This study uses daily saliva and nasal samples to track SARS-CoV-2 genetic variants in infected individuals, revealing stochastic evolution, mutational hotspots, and compartmentalization between sample sites.

The evolutionary potential of the influenza A virus hemagglutinin is highly constrained by intersegment epistasis

This study shows that intersegment epistasis between hemagglutinin and neuraminidase constrains the evolutionary potential of the influenza A virus hemagglutinin gene.

Interactions between influenza A virus nucleoprotein and gene segment UTRs facilitate selective modulation of viral gene expression

This study identifies how influenza A virus nucleoprotein interactions with gene segment UTRs selectively modulate viral gene expression, revealing a new role for NP in gene-segment specific regulation.

Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy

This study investigates the competition between influenza A virus and its defective interfering particles (DIPs) during co-infection, identifying DIPs with superior antiviral efficacy as potential therapeutic candidates.

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAs

The paper analyzes deletion-containing viral genomes (DelVGs) in influenza A virus infection, revealing packaging inefficiencies and deletion hotspots.

Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.

Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response

This study quantifies how cellular co-infection affects influenza A virus production and the interferon response in two cell lines, revealing cell-type-dependent effects on viral kinetics and immune signaling.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

A common pattern of influenza A virus single cell gene expression heterogeneity governs the innate antiviral response to infection

This study identifies a common pattern of viral gene expression heterogeneity in influenza A virus that influences host antiviral responses across subtypes.

Influenza A virus superinfection potential is regulated by viral genomic heterogeneity

This study identifies that the number of viral genes expressed, not their identity, determines influenza A virus superinfection susceptibility.