ImmunologybioRxiv
Corticosteroids and cellulose purification improve respectively the in vivo translation and vaccination efficacy of self-amplifying mRNAs
Z. Zhong, S. Mc Cafferty, L. Opsomer…·N. Sanders
This study shows that corticosteroids and cellulose purification enhance sa-mRNA translation and vaccination efficacy by reducing innate immune responses.
DOI 10.1016/j.ymthe.2021.01.023