VSTM1-v2 does not drive human Th17 cell differentiation
H. J. von Richthofen, F. M. J. Hafkamp, A. van Haperen…·L. Meyaard
This study shows VSTM1-v2 does not enhance DC-driven or cytokine-driven Th17 cell differentiation in human naive CD4+ T cells.
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3 papers
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H. J. von Richthofen, F. M. J. Hafkamp, A. van Haperen…·L. Meyaard
This study shows VSTM1-v2 does not enhance DC-driven or cytokine-driven Th17 cell differentiation in human naive CD4+ T cells.
H. J. von Richthofen, G. H. A. Westerlaken, D. Gollnast…·L. Meyaard
The paper shows that activated neutrophils release soluble SIRL-1 via proteinase 3 cleavage, and that sSIRL-1 is present in vivo in RSV and COVID-19 patients.
M. Rumpret, H. J. von Richthofen, M. van der Linden…·L. Meyaard
This study identifies S100 proteins as ligands for the inhibitory receptor SIRL-1, showing that SIRL-1 suppresses neutrophil ROS production via binding to S100A6.