Cancer BiologybioRxivPreprint
Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.
S. Khurshid, M. Montes, D. F. Comiskey…·D. Chandler
This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.
DOI 10.1101/2020.10.02.324053