F. Rigo

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

This study shows that loss of stathmin-2 causes neurofilament-dependent axonal collapse, leading to motor and sensory deficits and denervation in mice.

The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways

This study identifies MaTAR20 as a lncRNA that promotes mammary tumor growth by regulating angiogenesis pathways, specifically through its interaction with Tnfsf15.

PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR

The paper identifies PHAROH, an lncRNA overexpressed in hepatocellular carcinoma, which regulates c-Myc translation by sequestering TIAR, impacting cell proliferation and migration.

Relevance of Antibodies against the Chicken Anaemia Virus

This study shows that maternally-derived antibodies against Chicken Anaemia Virus (CAV) are not correlated with protection in broiler chicks, challenging their use as a sole indicator of immunity.

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.

This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.

ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

This paper demonstrates that ASO-based PKM splice-switching therapy inhibits HCC cell growth by converting PKM2 to PKM1, altering glucose metabolism and reducing tumorigenesis.

MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

This study identifies MaTAR25 and its human ortholog LINC01271 as lncRNAs that regulate Tns1 expression, impacting breast cancer progression through actin cytoskeleton and focal adhesion changes.