Suppression of p16 increases nucleotide synthesis via mTORC1
R. Buj, C.-W. Chen, E. S. Dahl, K. E. Leon, R. Kuskovsky, N. Maglakelidze, M. Navaratnarajah, G. Zhang, M. T. Doan, H. Jiang, M. Zaleski, L. Kutzler, H. Lacko, Y. Lu, G. B. Mills, , K. M. Aird
This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.
bioRxiv · Jul 20, 2019Cancer Biology