Cancer BiologybioRxiv
Suppression of p16 increases nucleotide synthesis via mTORC1
R. Buj, C.-W. Chen, E. S. Dahl…·K. M. Aird
This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.
DOI 10.1016/j.celrep.2019.07.084