Author

H. Lyoo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bosshart· 2 shared A. Cornelius· 2 shared A. Neculcea· 2 shared A. Schlegel· 2 shared C. Iss· 2 shared C. Wang· 2 shared C. Zitt· 2 shared D. L. Hurdiss· 2 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Bosshart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

S. Rothenberger, D. L. Hurdiss, M. Walser, F. Malvezzi, J. Mayor, S. Ryter, H. Moreno, N. Liechti, A. Bosshart, C. Iss, V. Calabro, A. Cornelius, T. Hospodarsch, A. Neculcea, T. Looser, , Vassell

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

bioRxiv · Feb 3, 2021 · PreprintImmunology

Highly potent anti-SARS-CoV-2 multivalent DARPin therapeutic candidates

M. Walser, S. Rothenberger, D. L. Hurdiss, A. Schlegel, V. Calabro, S. Fontaine, D. Villemagne, M. Paladino, T. Hospodarsch, A. Neculcea, A. Cornelius, P. Schildknecht, M. Matzner, M. Haenggi, M. Franchini, , Stittela

This paper develops potent anti-SARS-CoV-2 DARPin therapeutics with low picomolar neutralization efficacy and reports their protective efficacy in a hamster model.

bioRxiv · Aug 25, 2020 · PreprintImmunology

Characterisation of the c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication

J. A. McPhail, H. Lyoo, J. G. Pemberton, R. M. Hoffmann, W. van Elst, J. R. P. M. Strating, M. L. Jenkins, J. Stariha, F. J. M. van Kuppeveld, T. Balla, J. E. Burke

This study characterizes the c10orf76-PI4KB complex, showing its role in maintaining Golgi PI4P levels and enabling enterovirus replication.

bioRxiv · May 10, 2019Biochemistry

ACBD3 is an essential pan-enterovirus host factor that mediates the interaction between viral 3A protein and cellular protein PI4KB

H. Lyoo, H. M. van der Schaar, C. M. Dorobantu, J. R. P. M. Strating, F. J. M. van Kuppeveld

This study identifies ACBD3 as an essential host factor mediating 3A protein interaction with PI4KB, crucial for enterovirus replication.

bioRxiv · Aug 2, 2018Microbiology