Author

R. M. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

J. E. Burke· 3 shared M. L. Jenkins· 2 shared B. R. S. Temple· 1 shared E. Siraliev-Perez· 1 shared F. J. M. van Kuppeveld· 1 shared H. Lyoo· 1 shared H. Wang· 1 shared J. A. McPhail· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

J. E. Burke

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Author profile →

3 papers

Recent·Most cited

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

E. Siraliev-Perez, J. Sondek, B. R. S. Temple, Q. Zhang, N. Hajicek, J. E. Burke, J. T. Stariha, R. M. Hoffmann, M. L. Jenkins

This study shows that PLC-gamma1 becomes active upon binding to FGFR1 kinase domain and membrane-bound PIP2, with an oncogenic mutation enhancing this activation.

bioRxiv · Feb 23, 2022Biochemistry

The middle lipin (M-Lip) domain is a new dimeric protein fold that binds membranes

W. Gu, S. Gao, H. Wang, K. D. Fleming, R. M. Hoffmann, J. W. Yang, N. M. Patel, Y. M. Choi, J. E. Burke, K. Reue, M. V. Airola

The paper identifies the M-Lip domain as a novel dimeric protein fold that binds membranes and is essential for lipin function.

bioRxiv · Mar 19, 2021Biochemistry

Characterisation of the c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication

J. A. McPhail, H. Lyoo, J. G. Pemberton, R. M. Hoffmann, W. van Elst, J. R. P. M. Strating, M. L. Jenkins, J. Stariha, F. J. M. van Kuppeveld, T. Balla, J. E. Burke

This study characterizes the c10orf76-PI4KB complex, showing its role in maintaining Golgi PI4P levels and enabling enterovirus replication.

bioRxiv · May 10, 2019Biochemistry