Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection
S. Aggarwal, F. C. Walker, J. S. Weagley, B. T. McCune, X. Wu, L. Schreifer, H. Makimaa, D. Lawrence, P. Sridhar, M. T. Baldridge
This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.
bioRxiv · Feb 22, 2024Microbiology