R. Xu

Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases

The paper identifies gut microbiota-associated bile salt hydrolases (BSHs) with distinct substrate preferences using chemoproteomic profiling.

Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory

The paper identifies TMN CD4+ T cells that persist after YFV vaccination and contribute to long-term immunological memory.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum

This study investigates meiotic processes in Cryptosporidium parvum by analyzing chromosome segregation and recombination rates using transgenic parasites and in vitro cultures, revealing Mendelian inheritance and high crossover rates.

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

Orally delivered biodegradable targeted inflammation resolving pectin-coated nanoparticles induce anastomotic healing post intestinal surgery

This paper develops pectin-coated nanoparticles that deliver an inflammation-resolving peptide to the colon post-surgery, improving anastomotic healing in a murine model of colitis.

Targetable leukemia dependency on noncanonical PI3Kγ signaling

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

Tissue stiffness mapping by light sheet elastography

This paper introduces light sheet elastography to map tissue stiffness in embryos, enabling noninvasive, high-resolution analysis of mechanical changes during development.

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

This paper introduces a trizonal model to predict cancer cell shape transitions under ECM stiffening, revealing three motility zones and their implications for invasion.

Viscoelastic Deformability Cytometry: Ultra-high Throughput Platform for Mechanical Phenotyping of Cells in Liquid and Solid Biopsies

This paper introduces a high-throughput microfluidic platform for measuring cell mechanical properties in liquid and solid biopsies, enabling rapid and accurate mechanical phenotyping of cancer cells.

Chemical proteomic approach for in-depth glycosylation profiling of plasma carcinoembryonic antigen in cancer patients

This paper develops a chemical proteomic method to profile site-specific glycosylation of low-abundance plasma CEA in cancer patients, revealing differential glycoforms associated with cancer types and progression stages.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

This study identifies multiple pathways for glucose phosphate transport and utilization in Cryptosporidium parvum, revealing alternative mechanisms for obtaining phosphorylated hexose.

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth

The paper identifies indole metabolites from the microbiota that inhibit Cryptosporidium parvum growth by disrupting host mitochondrial function and parasite mitosome membrane potential.

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

This study shows the retinal pigment epithelium uses proline nitrogen to produce and export amino acids to the neural retina, highlighting its role in retinal metabolism.

Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

Leptospira transcriptome sequencing using long-read technology reveals unannotated transcripts and potential polyadenylation of mRNA molecules

This study uses long-read sequencing to analyze Leptospira transcriptomes, identifying unannotated transcripts and potential polyadenylation, with implications for virulence.

Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis

The paper identifies palmitoylation of GSDMD at Cys191/Cys192 as essential for its membrane translocation and pore-forming activity in macrophages.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Tissue-specific sex difference in mouse eye and brain metabolome under fed and fasted states

This study identifies tissue-specific and state-dependent sex differences in metabolomes of mouse eye and brain tissues under fed and fasted conditions.

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins

This study shows that the Drosophila Toll pathway and specific Bomanins enhance resilience to Aspergillus mycotoxins by mitigating toxin effects rather than directly killing pathogens.

Leptospira enrichment culture followed by ONT Nanopore sequencing allows better detection of Leptospira presence and diversity in water and soil samples.

The paper compares methods for detecting Leptospira in environmental samples, finding that enrichment culture followed by PCR or sequencing improves detection of both pathogenic and nonpathogenic Leptospira.

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

Selection of software and database for metagenomics sequence analysis impacts the outcome of microbial profiling and pathogen detection

This study evaluates how different metagenomics software and databases affect microbial profiling and pathogen detection in wild rodent samples.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal degeneration

This study shows IDH3B is essential for spermiogenesis but not retinal health, as Idh3b-knockout mice are infertile but have normal vision.

Mast Cell Derived Histamine Negatively Regulates Hematopoiesis

This study shows mast cell-derived histamine suppresses hematopoietic stem cell function, as evidenced by increased hematopoiesis in histamine-deficient mice and reversal with exogenous histamine.