M. T. Baldridge

This study shows that sequential early-life viral infections in mice reduce antibody responses to SARS-CoV-2 vaccination while altering immune cell profiles and gut microbiota.

The paper identifies indole metabolites from the microbiota that inhibit Cryptosporidium parvum growth by disrupting host mitochondrial function and parasite mitosome membrane potential.

The paper identifies Pou2af2 isoform usage as a regulator of tuft cell differentiation and intestinal type 2 immunity through genetic mapping in mice.

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.