Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor
S. Kumar, J. Zhao, S. Talluri, L. Leutz Buon, S. Mu, B. Potluri, C. Liao, J. Shi, C. Chakraborty, G. B. Gonzalez, Y.-T. Tai, J. Patel, J. Pal, H. Mashimo, M. K. Samur, , M. A. Shammas
This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.
bioRxiv · Apr 20, 2022 · PreprintCancer Biology